Cognilace™ contains Phytotherapeutic Extracts of Astragulus membracanus,Salvia miltiorrhiz, Radic Paoenia rubras, Polygonum multiflorum, Dryobalanops aromatica (Borneal), Callus spatholobi and Cinnamomum vera.
The principal action of Cognilace is in modulating the Integrated Stress Response (ISR) by modulating the PERK pathways that induce the sustained PERK signaling associated with chronic or severe endoplasmic reticulum (ER) insults. Imbalances in ER proteostasis can propagate to extracellular environments through the secretion of proteins in non-native conformations that accumulate as toxic oligomers and aggregates associated with proteotoxicity in etiologically diverse protein aggregation diseases, including many amyloid diseases. Consistent with a role for PERK in dictating both protective and pro-apoptotic responses to specific ER insults, imbalances in PERK activity caused by genetic, environmental, or aging-related factors is implicated in the pathogenesis of diverse diseases. Sustained PERK signaling associated with chronic or severe ER insults is implicated in neurodegeneration associated with diseases such as Alzheimer’s disease and prion disease.
Ingredients: Astragulus membracanus, Salvia miltiorrhiz, Radic Paoenia rubras, Polygonum multiflorum, Dryobalanops aromatica (Borneal), Callus spatholobi and Cinnamomum vera.
1 dropper full or 1 ml per dose.
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